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Experimental group abbreviations: S sham-operated rat group, S + M sham-operated + meldonium rat group, I/R ischemia/reperfusion rat group, I/R + M ischemia/reperfusion + meldonium rat group

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Prooxidants are defined as substances that induce oxidative stress, often by generating reactive species or by inhibiting antioxidant systems (Puglia and Powell 1984)

Plasma acylcarnitine profiles generally provide more robust and reproducible indicators of systemic metabolic disturbance, and selected signatures may outperform the urinary albumin-to-creatinine ratio (UACR) in the early detection of DKD

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