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This process, termed granulopoiesis, strengthens host defense, but Clostridium perfringens -toxin impairs granulopoiesis via an unknown mechanism

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Additionally, hypothalamic cellular models demonstrate increased intracellular cAMP production and elevated expression of anorexigenic neuropeptides following melanocortin receptor stimulation

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We tested PLC2 with a c-terminal deletion of both the proximal CTD and distal CTD (PLC2-818) and a mutation (PLC2-P819A) predicted to disrupt formation of the helix loop helix conformation of the proximal CTD that is stabilized upon G q binding (Figure 7A)