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Low levels of artificial light at night (5 lux) disrupt circadian rhythmicity with a reduction in Per1 and Per2 expression in the SCN, concurrent with altered expression of Bmal1, Per1, Per2 , and Cry1 in the liver of mice ( Night Shift Work, Travel, and Social Jet Lag Coinciding with the increase in light pollution as a result of industrialization, current society has deviated from 9 to 5 workdays

doi: 10.3748/wjg.v27.i39.6715 214 SuY-NWangM-JYangJ-PWuX-LXiaMBaoM-Het al

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After randomization, participants completed monthly mid-study visits at 1-month (Month 1), 2-month (Month 2), and the end of study visit at 3 months (Month 3) for the final measurement of outcomes of interest, including the final MR scan

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