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Human clinical trials could help establish the efficacy of any opioid sparing effects of vitamin B12 for patients with chronic pain

NNMT takes nicotinamide, a form of vitamin B3, and attaches a methyl group to it, using SAM (S-adenosylmethionine) as the methyl donor

This information should not be used to decide whether or not to take this medicine or any other medicine

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However, the method requires the addition of radioactive cyanocobalamin to compete with vitamin B12 in the serum for the binding sites on an added cobalamin-binding protein

Payers require that the specific substance administered, along with the dosage and route of administration, be clearly identified on every claim