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For patients who dont respond to 3-6 months of conservative treatment, correction of extensor mechanism alignment problems (medial plication/lateral release, tibial tubercle osteotomy) and cartilage-oriented surgeries (arthroscopic patellar shaving, drilling of the defect that reaches subchondral bone, facetectomy, tibial tubercle proximal relocation, patellectomy, patellofemoral surface arthroplasty) may be needed.

The genes OsTGG1 (Oryza sativa thioamylase 1) and OsTGG2 (Oryza sativa thioamylase 2) are responsible for hydrolyzing specific GSLs, particularly those in the aliphatic class, into active derivatives such as isothiocyanates

ENL and AF9 are representative proteins containing the YEATS domain and are key drivers of various malignancies, including mixed-lineage leukemiarearranged acute leukemia [267]

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