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Evidence indicates that -syn deposition is observed in the livers of both PD models and patients, showing an age-related distribution pattern [42, 95]

MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

Therefore, an elevated level of Hcy is relatively well explored in association with oxidative stress [109], and Hcy-associated ROS promote lipid peroxidation resulting in oxidative damage of cellular molecules [108]

10.3390/pharmaceutics12030269 119 WangG.YuF.TaoZ.DengS

10.1111/j.1365-2958.2009.06763.x 116 PortmannR.PoulsenK

204 Although Gadd45a has been linked to the global DNA methylation and transcriptional regulation, Gadd45a loss does not change the global DNA methylation pattern in our experimental setting, 204 indicating that manipulation of the Gadd45a gene could delay organ ageing, and prolong the health span and life span of premature ageing mice