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Rodriguez-Otero P, DSouza A, Reece DE, et al

Methotrexate belongs to a class of drugs known as antimetabolites

Current evidence suggests that simple fatty liver does not directly cause B12 deficiency, but the metabolic conditions, medications, and dietary patterns often associated with fatty liver can increase deficiency risk

Absorption happens through the oral mucosa and bypasses first-pass liver metabolism

Behav Neurol 2022:4797861 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhou Z, Zhou R, Zhang Z, Li K (2019) The association between vitamin D status, vitamin D supplementation, sunlight exposure, and parkinsons disease: a systematic review and meta-analysis

Its also essential to note that while a B12 deficiency may contribute to cognitive decline, it is not the sole cause of dementia, Dr
