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4L, M and S9B), potentially due to the technical limitations associated with delivering GSH to adult animals

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Despite their prevalence in the human diet, natural antioxidants, particularly dietary flavonoids, have largely failed to demonstrate therapeutic efficacy and may not serve as suitable templates for drug development

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114 Similar effects are observed in liver cancer, 115 pheochromocytoma 116 and NSCLC, 111 and NNT is likely to be activated by NADPH consumption, such as in IDH-mutant cells

Primary Handling Editor: Jerome Staal, in collaboration with the Nature Medicine team