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PATHOPHYSIOLOGY AND MECHANISMS Migraine is a complex and disabling neurological disorder, more prevalent in women, whose pathophysiology involves neurovascular mechanisms, mitochondrial dysfunction, neurogenic inflammation, and oxidative stress

therefore, both must be considered when discussing the effects of TMAO

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FEBS Lett 495(12):1215
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Morphological and functional characteristics of the graft, as well as the target vessel (including degree of stenosis, vessel diameter, and atherosclerotic burden of the distal vascular bed), technical factors (such as harvesting technique, intraoperative graft storage and preservation, and anastomotic technique), and underlying patient-related atherosclerotic risk contribute to the multifactorial process of graft failure
