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Whereas cancer combatting effects were seen with PCSK9 inhibition in the studies discussed previously, no tumor growth reduction or survival benefit was seen with the use of anti-PCSK9 vaccination in mice bearing melanoma tumors (Momtazi-Borojeni et al., 2020), and in fact, PCSK9 siRNA protected prostate cancer cells against ionizing radiation-induced cell damage by its anti-apoptotic activity in vitro (Gan et al., 2017)

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Carnitine levels are reduced in patients suffering Gram-negative sepsis and urinary loss of carnitine is proportional to the degree of injury [96]

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The translocator proteingene is associated with endogenous pain modulation and the balance betweenglutamate and gamma-aminobutyric acid in fibromyalgia and healthy subjects:a multimodal neuroimaging study