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Deficiencies of vitamin B12 are fairly common but it is difficult to know if you are deficient

Feb 24: This past weekend brought bad news for Oncopeptides as the FDA announced it would withdraw the approval of Pepaxto, which was greenlit in March 2021, in combination with dexamethasone, to treat certain patients with multiple myeloma

In addition, vitamin B-12 status in the mother was also related to neonatal vitamin B-12 status as measured by cord plasma vitamin B-12 concentrations

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CagriSema: Cagrilintide + Semaglutide dosing Simultaneous start (from day 1): Semaglutide titration: Weeks 1-4: 0.25mg weekly Weeks 5-8: 0.5mg weekly Weeks 9-12: 1.0mg weekly Weeks 13-16: 1.7mg weekly Week 17+: 2.4mg weekly Cagrilintide titration (running parallel): Weeks 1-4: 0.6mg weekly Weeks 5-8: 1.2mg weekly Weeks 9-12: 1.8mg weekly Week 13+: 2.4mg weekly CagriSema vs monotherapy comparison: Key points: Both injected same day (different sites) OR different days Cagrilintide reaches target faster (13 weeks vs 17 weeks) Side effects additive but manageable Maximum synergy Sequential start (adding cagrilintide later): Already on semaglutide 2.4mg: Stable on semaglutide for 4+ weeks Continue semaglutide 2.4mg weekly Add cagrilintide starting 0.6mg weekly Titrate cagrilintide: 0.6mg (weeks 1-4) 1.2mg (weeks 5-8) 1.8mg (weeks 9-12) 2.4mg (week 13+) Maintain both at 2.4mg Advantages of sequential: Semaglutide establishes baseline weight loss first Easier to attribute new side effects (know it's cagrilintide) Less overwhelming than both at once Can see incremental benefit of adding cagrilintide Expected combination results: 15-20% average weight loss (most users) 20-25% weight loss (excellent responders) Superior to either alone consistently Optimize your CagriSema protocol at SeekPeptides - we help you coordinate both titration schedules and manage combined side effects
