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TGR5 and Its Physiologic Effects Relevant to GLP-1 and Glycogen Metabolism Takeda G protein-coupled receptor 5 (TGR5), a G protein-coupled bile acid receptor, contributes to improved hepatic insulin sensitivity and subsequent energy metabolism and homeostasis [139]

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Since tolerability remains a hurdle in the widespread adoption of GLP-1 treatments, experts at the summit discussed the potential of these combination therapies to mitigate treatment side effects and improve patient adherence

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Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, et al

Many patients notice early improvements in appetite and energy within the first few weeks