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Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD)

However, each member of the GPX family has a different mechanism of action and site of action in maintaining redox balance

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J Natl Cancer Inst 1997

Furthermore, within squamous cell carcinoma there is a dramatic increase in the expression of many enzymes of the glutathione metabolic pathway related to its antioxidant function and synthesis [61]