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PTMs, including phosphorylation, ubiquitination, and acetylation, play a pivotal role in modulating NRF2s stability, activity, and subcellular localization, thereby precisely controlling its function in the antioxidant response

doi: 10.23876/j.krcp.19.063 69 XuNJiangSPerssonPBPerssonEAGLaiEYPatzakA

doi: 10.3389/fmicb.2021.658292 175 XuL.LiuB.HuangL.LiZ.ChengY.TianY.et al

First, an arginine (R) at the third position is swapped for a glutamic acid (E)

Dalmau, J., Geis, C

Many of these reactions generate free radicals that can, if not controlled (neutralized), cause damage inside the body in the form of oxidative stress