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Over the past decade, extensive studies have revealed critical roles of the tumour microenvironment (TME) in cancer initiation, progression, and drug resistance

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This process is pivotal for cellular respiration

Importantly, we find that the ISR pathway is required for efficient epithelial cell differentiation and lytic EBV reactivation in NOKs and show that expression of CHOP alone is sufficient to induce lytic EBV reactivation and differentiation