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10.1182/blood.v92.4.1191.416k15_1191_1198 32 La TorreG.CalzoniL.ColamestaV.GuzzoA

It is characterized by progressive neurodegeneration and hypertrophic cardiomyopathy caused by severely reduced levels of frataxin, a mitochondrial chaperone protein involved in ironsulfur cluster assembly [89]

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Once these pathways are identified, the application of precision medicine can be fully realised through endpoints like (differential) biomarker-based diagnostics, patient subgrouping, and personalised treatments targeting specific pathways

These problems may be associated with increased afterload, left ventricular stiffening, chamber remodeling, and an elevated risk of developing heart failure [127, 128]

Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated