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Key physiological features of the hypothalamo-pituitary-adrenal (HPA) axis are discussed, including the ultradian pulsatility of CRH, AVP and ACTH secretion, the circadian pattern of secretion, the negative feedback of cortisol on the HPA axis, the stress response, and the effects of aging and gender

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The discovery of lactylation, a novel post-translational modification, has uncovered the role of lactate in regulating diseases, especially in the brain

Chan JL, Bluher S, Yiannakouris N, Suchard MA, Kratzsch J, Mantzoros CS

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Also, Mettl3 can increase c-Myc and Avpr2 mRNA modification, activate c-Myc and cAMP pathways, and accelerate cyst growth