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The TCA cycle metabolite, succinate, (as succinyl-CoA) is utilized for the succinylation of lysine (Ksucc) residues in histone proteins which represents a critical epigenetic modification
doi: 10.1017/S1461145712000302 152 TapieroHBaGNCouvreurPTewKD
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Some engineered tags also allow conditional control, such as pH or ligand-dependent stabilization, thus expanding their utility in synthetic biology and therapeutic design
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Glycine-based treatment ameliorates NAFLD
