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267 While there is a need in clinical research to enroll a more homogeneous patient population, this approach raises concerns about the clinical relevance of such studies for the truly heterogeneous IC/BPS population

ADAR2 is believed to operate predominantly in the brain, with its clinical relevance linked to neurological functions, including the editing of aminomethylphosphonic acid receptors, disturbances of which may result in persistent seizures and mortality (47)

These symptoms are usually mild and self-resolving

Diet-induced extinctions in the gut microbiota compound over generations