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These considerations are routinely accounted for within controlled study protocols
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[2] When used in supplementation, all of the vitamin B 12 vitamers have been argued to be beneficial, with there not being clear evidence that any are relatively more or less effective

Funding Statement This work was supported by grants from The Regional Innovation and Development Joint Fund of National Natural Science Foundation of China (U22A20269), the Fundamental Research Funds for the Central Universities (2042023kf0045), the National Natural Science Foundation of China (82170246) and the National Key R&D Program of China (2018YFC1311300)

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