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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ME/CFS is defined as persistent or relapsing fatigue for at least six months, which is not resolved by rest, and causes a substantial reduction in the Activity of Daily Living (ADL) 206

The second enzyme that requires vitamin B12, L-methyl-malonylcoenzyme A mutase, utilizes deoxyadenosylcobalamin to convert L-methylmalonyl-coenzyme A to succinyl-coenzyme A, a reaction involved in the metabolism of branch chain amino acids and odd chain fatty acids

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