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Description
The proposed mechanism of action is the inhibition of ceramide synthase by occupying sphingosine and fatty acyl-CoA interactions
These effects of acrolein were blocked by NAC and GSH (Jeong and Kang, 2008)
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They all possess the highly conserved HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzyme activities (Luan et al., 2012)
Thus, the Acr-GSH adduct can accumulate before the enzyme systems significantly mediate the oxidation or reduction pathways of metabolic degradation 16,17,18
The mechanism that emerges from our anal
