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Unlike receptor-specific agonists, DSIP is investigated for its broader neuro-modulatory profile and interactions within hypothalamicpituitary signaling networks, making it of interest in sleep and endocrine research models

This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification

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