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10.1016/j.cmet.2019.01.018 33 MansourG

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

High-quality randomized trials focused specifically on weight outcomes in non-deficient populations would clarify these uncertainties

Notably, individuals with more advanced liver disease exhibited the highest endogenous BAC, and BAC could be manipulated to increase or decrease by pre-treating patients with an infusion of an inhibitor of hepatic alcohol metabolism (4-methylpyrazole) or with a course of broad-spectrum antibiotics, respectively (63)

The weak signals might be attributed to the accumulation of excess PITC reagent unreacted and reaction byproducts from repeated cycles of Edman degradation