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Taken together, decrease in expression of inflammatory markers such as pro-inflammatory cytokines and chemokines and infiltration of pro-inflammatory macrophages in adipose tissue of Cpt1b m/ mice indicates that inflammatory status is improved in adipose tissue despite the elevated levels of lipids in circulation

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Key finding: NNMT overexpression drives satellite cell senescence pharmacological inhibition with 5-Amino-1MQ restored stem cell activation to levels comparable to young animals

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