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In AD, highly phosphorylation and aggregation of tau protein contribute to the formation of NFTs and to mediate A toxicity
A number of underlying mechanisms have been proposed, including increased oxidative stress, disruption of normal hormonal and neurological signaling, impaired cellular and mitochondrial processes, formation of abnormal proteins, and DNA damage

Overall, remarkable improvements in depressive symptoms and quality of life were observed

& Rayens, W

Finally, the immature (or nascent) CL is converted into its mature form by the acyltransferase Tafazzin
