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Since the 5 -reductase-1 activity is 3 to 4 times greater in malignant than in benign prostate tissues, while the 5 -reductase-2 activity is similar in these 2 diseases 91 , whether inhibition of both isozymes by combination of specific type 1 and type 2 inhibitor or using dual inhibitor is more effective in the prevention and therapy of prostate cancer is an interesting strategy and remains to be determined

Lymphoma 62 , 11871194 (2021)

The interplay between gut microbiota and EECs mostly occurs through different microbial metabolites, with a central role of SCFAs and tryptophan, as it will be later discussed

Endothelial dysfunction in hypertension: current concepts and clinical implications

644 This local acidification increases the expression of vascular endothelial growth factor A, further promoting cancer cell proliferation 645 and modifying other metabolic pathways
