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If headaches continue after the initial adjustment period, dropping from 500mcg to 300mcg might help

Reduced expression of PGC-1 partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex

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doi: 10.1016/j.ejphar.2011.01.013

Exp Biol Med (Maywood) 240(8):9971007 Huang AS, Beigneux A, Weil ZM, Kim PM, Molliver ME, Blackshaw S, Nelson RJ, Young SG, Snyder SH (2006) D-aspartate regulates melanocortin formation and function: behavioral alterations in d-aspartate oxidase-deficient mice