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The overall lower total organic content for the FA-conjugated material (30%) compared with the non-conjugated drug-loaded SBA-15 (50%) implies that conjugation reduced the amount of physically adsorbed (free) drug for example by replacing weakly adsorbed drug with covalently tethered folic-aciddrug species or by additional washing steps removing unbound drug

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In other studies, no changes in the content of folic acid, which was used for the fortification of wheat flour, during the main four stages of instant fried Asian noodle manufacturing (mixing, sheeting and cutting, steaming, and frying) were observed 455,456