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By blocking TREK-1, PE-22-28: Increases neuronal excitability : Reduces potassium efflux, depolarizing neurons toward firing threshold Enhances serotonergic transmission : TREK-1 is expressed on serotonergic neurons in the dorsal raphe nucleus

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MOR202 and Mezagitamab bind with high specificity to CD38 on the surface of multiple myeloma cells 150,151 inducing apoptosis through ADCC and antibody-dependent cellular phagocytosis (ADCP) 152,153