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Drug Res (Stuttg) 65:555560

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[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Peake J.M., Roberts L.A., Figueiredo V.C., Egner I., Krog S., Aas S.N., Suzuki K., Markworth J.F., Coombes J.S., Cameron-Smith D., et al

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1 Overview of Lynch syndrome and associated cancer risks Lynch syndrome (LS) is a hereditary condition that predisposes individuals to various malignancies, most notably colorectal cancer (CRC) and endometrial cancer (EC) ( MLH1 and MSH2 genes are observed in only a small percentage of sporadic cases ( MLH1 gene by promoter hyper-methylation, a phenomenon also observed in LS

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