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Besides, Phosphoinositide 3-kinase (PI3K)/Akt signaling regulates cell survival and oxidative stress responses
c , Expression of Agxt , Grhpr , Prodh2 , Hoga1 , Hao1 , and Ldha relative to Gapdh , ( d, e ) protein abundance and quantification of AGXT, and ( f, g ) LDHA relative to -Actin, ( h ) LDH activity, and ( i ) oxalate concentrations normalized to tissue weight in liver samples from mice with (n=6) or without early MASH (12 weeks, n=6)
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The mechanism mainly relies on stimulating lipid synthesis and accumulation, rather than on direct conversion of fructose to fatty acids [109]
However, the seleno-protein GPx2 plays an important role in the progression of malignant tumors [312]
