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Considering the promise of cholesterol depletion in combatting cancer, the known role of PCSK9 inhibition in lowering cholesterol, and the previously described effects of PCSK9 in facilitating cancer progression, PCSK9 inhibition therapy may be uniquely suited for cholesterol depletion-mediated anticancer effects (Gangloff et al., 2017).PCSK9 knockout was protective against melanoma metastasis in the liver of mice, whereas a high-cholesterol diet reversed this effect (Sun et al., 2012)

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[DOI] [PubMed] [Google Scholar] Vescovo G., Ravara B., Gobbo V., Sandri M., Angelini A., Barbera M.D., Dona M., Peluso G., Calvani M., Mosconi L., Libera L.D