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While Y chromosome loss is not associated with changes in tumor growth, tumor grade, and tumor stage of bladder tumors, specifically [100], recent work shows that deletion of the Y chromosome by CRISPRCas9 contributes to immune dysfunction in the TME and better response to immune checkpoint blockade [101]

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Moslehi N, Zeraattalab-Motlagh S, Rahimi Sakak F, Shab-Bidar S, Tehrani FR, Mirmiran P

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