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On the other hand, the administration of the treatment can be very debilitating for those who have skin problems, so it might not be appropriate for all scenarios

*Correspondence: Fei Mao, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

There's no evidence of tachyphylaxis (desensitization) with AOD-9604 since it doesn't affect the GH axis, but cycling is still recommended due to limited long-term human data

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In addition, the conversion of Hcy to Met is catalyzed by 5-methyltetrahydrofolate-homocysteine methyltransferase (MS), a B12-dependent enzyme that uses (5-methyl-THF) the derivative of folate as a methyl donor (Fig