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Folate, B12 And MTHFR MTHFR stands for methylene-tetra-hydro-folate reductase , an enzyme that reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate

Free Radic Biol Med 2009

The shared molecular binding of the brains vitamin B12 carrier protein, known as transcobalamin 2 or TCN2, with the FDA-approved MS drug fingolimod, provides a mechanistic link between B12 signaling and MS, towards reducing neuroinflammation and possibly neurodegeneration, said Chun, a professor in the Center for Genetic Disorders and Aging Research at Sanford Burnham Prebys

Jariwala SP

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The same vascular-protective signalling appears to underpin the rapid restoration of blood supply observed in ischaemia-reperfusion colitis models [PubMed]