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We created the CureGPX4 Roadmap by working backwards from patient needs, aiming for therapies which may first slow, then halt, and finally reverse disease progression

Ascorbic acid is derived from glucose via the uronic acid pathway, however, the enzyme L-gulono--lactone oxidase responsible for the conversion of gulonolactone to ascorbic acid is absent in primates making ascorbic acid required in the diet

[19] [21] The duration of therapy depends on the indication and patient response

* Correspondence: Vanessa Castelli, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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