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The mechanism of Pb 2+ toxicity involves altered mitochondrial permeability, the release of mitochondrial proteins resulting in the apoptosis of brain cells, an increase in the proapoptotic Bax/Bcl-2 ratio via the downregulation of the antiapoptotic protein Bcl-2, and the upregulation of the proapoptotic protein Bax (Pulido and Parrish 2003

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doi: 10.3109/03602532.2011.558093 McIlwain et al.,2006 McIlwain CC, Townsend DM, Tew KD(2006)Glutathione S-transferase polymorphisms: cancer incidence and therapy Oncogene 25(11):1639-48 Hayes et al.,1995Hayes JD, Pulford DJ.(1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

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