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Peptide chemists will use non-natural amino acids, backbone modifications, and cyclization to increase stability and half-life from minutes to hours or days, which cuts dosing frequency

Inflammatory mediators like cytokines, ROS, and reactive nitrogen species derived from tumor-infiltrating immune cells induce epigenetic alterations in premalignant lesions and silence tumor suppressor genes in the initial phase of tumor development (Multhoff et al., 2012)

a compound proposed to potentiate c-Met raises a legitimate, uncharacterized theoretical risk of promoting proliferation [5]

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