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Results Specificity of the UPLC-MS/MS method There was no interference between the retention times of the internal standard (IS, gliclazide) and SEI in plasma samples

Biochem Biophys Res Commun 2018;495:20411

The biotransformations carried out by the microbiota include hydrolysis, oxidation, reduction, and isomerization reactions, which alter the chemical structure, pharmacological activity, and toxicity of TCM compounds, generating new active metabolites

[PubMed] [Google Scholar] 130.Hurt K.J., Musicki B., Palese M.A., Crone J.K., Becker R.E., Moriarity J.L., Snyder S.H., Burnett A.L

Through innovation in materials science, optimization of production processes and quality control, in-depth study of nano-bio interface interactions, assessment through long-term clinical studies, cost reduction through scaled production and technological innovation, and well-designed clinical trials, the prospects for clinical application of nanomedicine will become increasingly promising

For best results, doses should be taken in morning and at lunch