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Moreover, pretreatment with gemcitabine, a DNA-damaging agent, significantly enhances the cytotoxicity of BRAF inhibitors against resistant melanoma, pancreatic cancer and non-small cell lung cancer cells (130)
The terminal half-life after intravenous administration was 1.95 h
The DNA methylation process of NRF2 regulates its gene expression by adding Me groups to the CpG islands in its promoter region
PubMed, Raffield, Laura M., et al
& Paternostro, G
