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In the next sections, we will briefly introduce thiazides, thiazide-like and loop diuretics from a historic perspective to illustrate how the success of one specific class of these diuretics in treating hypertension overshadowed their undesired metabolic effects and reduced our curiosity to study them to better understand their basic and clinical pharmacology

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With regards to subacromial impingement the pathology involves a rotator cuff dysfunction resulting in a mechanical impingement and compression of the subacromial bursa between the rotator cuff and the acromion and coracocromial ligament

The DHRS2 encoded enzyme is a member of the short-chain dehydrogenase/reductase (SDR) family of oxidoreductases

Thus, contrary to what is seen in NER, patients with tumors deficient in MMR show resistance to cisplatin 13

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