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PEA has anti-inflammatory effects on the body by inhibiting the production of pro-inflammatory cytokines and by reducing the activity of activated microglia cells

The peptides administration has been linked to the release of serotonin in brain regions associated with mood and motor control, suggesting a bidirectional communication pathway between the gut and the brain

This suggestion was further insisted as a potential mechanism of TB-500 by the authors of the research study, who also commented that "transfection of anti-miR-146a nucleotides reversed the inhibitory effect of T4 on IRAK1 and TRAF6." Thus, TB-500 also appears to potentially work for healing by exerting anti-inflammatory action.(6)

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