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Description
Although GSH extrusion may provide a simple mechanism to circumvent the normally protective functions of GSH, there is increasing evidence that GSH export is required for activation of specific apoptotic signaling pathways and/or for proper dismantling of cellular components (Coppola and Ghibelli, 2000
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Additionally, DNA damage by oxidative stress frequently activates the SOS response pathway, which induces the UvrABC excision nuclease as well as the Rec recombinational machinery (Imlay and Linn, 1987)

10.3389/fimmu.2024.1380229 150 ZengW.QianJ.WangY.ShouM.KaiG
Their clinical utility urgently requires validation through well-designed, large-scale randomized controlled trials
Kapsogeorgou EK, Tzioufas AG (2016) Autoantibodies in autoimmune diseases: clinical and critical evaluation
