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After removing the bone flap, CCI was performed with a controlled impactor device at a speed of 4 m/s, a depth of 1 mm and a 150-ms impact duration (Impact One TM Stereotaxic Impactor, Leica, Milan, Italy)
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Further, substitution of Arg for Sec may not be a random amino acid insertion, as two of the six Arg codons (CGA and AGA) have only a single base difference with the UGA codon
