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Moreover, our results highlight the essential role of vitamin B12 in homocysteine metabolism, as supplementation was associated with a significant reduction in serum homocysteine levelsan important biomarker associated with cardiovascular and neurodegenerative diseases

Supplement dose for vitamin B12 in post-WLS patients varies based on the route of administration: Orally by disintegrating tablet, sublingual (under the tongue), or liquid: 350500 mg daily Nasal spray as directed by manufacturer Parenteral (IM or SQ): 1000 mg monthly Post-WLS patients with B12 deficiency should take 1000 mg/d to achieve normal levels and then resume dosages recommended to maintain normal levels

Nutritional deficiencies after sleeve gastrectomy and Roux-en-Y gastric bypass at 10 years: secondary analysis of the SLEEVEPASS randomized clinical trial

Further arguments might be controlling vasomotor tone and the activation of the Src-Caveolin-1-eNOS pathway [53,54]