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Examples Sitagliptin (Januvia) Dosage Initial: 25100 mg once daily (depending on kidney function) Maximum: 100 mg once daily Saxagliptin (Onglyza) Dosage Initial: 2.55 mg once daily Maximum: 5 mg once daily Linagliptin (Tradjenta) Dosage Initial: 5 mg once daily Maximum: 5 mg once daily Alogliptin (Nesina) Dosage Initial: 6.2525 mg once daily (depending on kidney function) Maximum: 25 mg once daily Possible side effects include: Acute pancreatitis (this appears to be rare) Severe joint pain Thiazolidinediones (TZDs) Primary mechanism(s) of action Modulation of glucose and lipid metabolism via activation of the PPAR-gamma nuclear hormone receptor

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It produces hormones that dysregulate appetite, increase cortisol sensitivity, and impair growth hormone secretion

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