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While high xCT activity can increase sensitivity to disruptions to glutamate or NADPH regeneration, it is not clear whether these mechanisms impair cell function in the absence of additional metabolic perturbations 4,5,9,11,44,45,46

Coenzyme Q10 (CoQ10) plays a critical role in cellular energy processes and exists in two forms: ubiquinol (reduced) and ubiquinone (oxidized)

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Abbreviations: in vitro , cell-based experimental systems