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These interconnected pathways illustrate how probiotics influence asthma pathogenesis through a hierarchical mechanism: gut microbial modulation as the upstream driver, epithelial and metabolic signaling as intermediate modulators, and immune cell reprogramming as downstream effectors

10.1038/nri.2016.88 43 KadotaT.FurusawaH.HiranoS.TajimaO.KamataY.Sugita-KonishiY

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Thus, what was once regarded as a highly stable and terminal epigenetic state, DNA methylation is becoming increasingly viewed as a more dynamic process

GreenbaumUStratiPSalibaRTorresJRondonGNietoYet alCRP and ferritin in addition to the EASIX score predict CAR-T-related toxicity