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Materials and methods There were 10 experimental groups (n = 68 rats/group)

doi: 10.1164/rccm.202202-0399ST

Non-consideration of these long-known and well-recognized pitfalls will inevitably lead to artificial oxidation of GSH to GSSG thus generating invaluable biased GSH/GSSG ratios, falsely cheating altered oxidative stress

At physiological pH, the thiol residue of GSH is scarcely deprotonated (pK a =9.2)

human efficacy is unproven and individual results vary

doi: 10.1172/jci.insight.159491 193 Subramanian VigneshKLandero FigueroaJAPorolloACarusoJADeepeGSJr.Granulocyte macrophage-colony stimulating factor induced zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival